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Ciprofloxacin is one of synthetic fluoroquinolone antibacterial agents which has great bactericidal activity against Gram negative aerobic organisms (especially, Enterobacteriaceae and Pseudomonas aeruginosa) and Gram positive bacteria (including Penicillinase-producing and Methicillin-sensitive Staphylococcus aureus). However, the appearance of ciprofloxacin resistant to many different microorganisms limits the use of ciprofloxacin for patients who are really needed it. This sudy was performed to analyzed the appropriateness for ciprofloxacin use in St. Mary´s Hospital setting. Forty-one charts of patients who used ciprofloxacin (Ⅳ) (M/F 24/17, Jan.-Aug. of 1998) underwent drug utilization evaluation (DUE). The criterias of DUE used in this study were based on the standards by the American Society of Hospital Pharmacy which modified to be appropriate in our hospital setting : 1) Justification of drug use, 2) Critical & process indications, 3) Complications, 4) Outcome measures. Justification of use showed high appropriate rate (87.8%). Most of the critical & process indications also showed high appropriate rates (82.9 thru 97.5%) except C&S test during ciprofloxacin use (60.9%). Complications in ciprofloxacin use were usually minor symptoms such as pruritis (2.4%) and GI problems (39.0%). Also these study datas demonstrated other factors such as drug-drug interactions and co-disease could influence the complications. In case of outcome measures, the total therapeutic response showed high rate (95.1%). Only two patients (4.8%) had no response to ciprofloxacin at all. This study shows DUE analyzed for the appropriateness and problems of ciprofloxacin use. Therefore, DUE to a specific drug can apply to improve the efficacy of drug use and quality of medical service.
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